0204: Proteome-wide sex-related differences in response to mouse thoracic aortic constriction: molecular bio-signature of failing hearts
نویسندگان
چکیده
منابع مشابه
Mechanical function, glycolysis, and ultrastructure of perfused working mouse hearts following thoracic aortic constriction.
BACKGROUND Glycolytic flux in the mouse heart during the progression of left ventricular hypertrophy (LVH) and mechanical dysfunction has not been described. METHODS The main objectives of this study were to characterize the effects of thoracic aortic banding, of 3- and 6-week duration, on: (1) left ventricular (LV) systolic and diastolic function of perfused working hearts quantified by anal...
متن کاملComparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6
Chronic pressure overload (PO) induces pathological left ventricular hypertrophy (LVH) leading to congestive heart failure (HF). Overexpression of FKBP12.6 (FK506-binding protein [K]) in mice should prevent Ca2+-leak during diastole and may improve overall cardiac function. In order to decipher molecular mechanisms involved in thoracic aortic constriction (TAC)-induced cardiac remodeling and th...
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Purpose: Toxoplasma gondii (T. gondii) is the causative agent of toxoplasmosis. It infects up to one third of the human population. The aim of this study was to evaluate the effects of T. gondii infection on induction of oxidative stress in serum of infected men and women. Materials and Methods: This case-control study was carried out on 150 individuals who had referred to our center ...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2014
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(14)71473-9